IgA-BINDING PEPTIDE AND PURIFICATION OF IgA THEREBY

摘要

This invention provides a peptide that comprises an amino acid sequence consisting of 14 to 18 amino acid residues represented by Formula (I) and is capable of binding to human IgA:
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒH-(X 1 )-V-C-L-S-Y-R-(X 2 )-(X 3 )-G-(X 4 )-P-(X 5 )-C-(X 6 )-(X 7 )-(X 8 )€ƒ€ƒ€ƒ€ƒ€ƒ(I) (SEQ ID NO: 1)
wherein each X is independently selected from among the following: X 1 represents a Gln residue or a Met residue; X 2 and X 3 each independently represent an arbitrary amino acid residue other than Cys or either or both thereof are deleted; X 4 represents an Arg residue or a Gln residue; X 5 represents a Val residue or a Thr residue; X 6 represents a Phe residue or a Tyr residue; X 7 represents a Ser residue or is null; and X 8 represents a Leu residue, a Thr residue, or is null, provided that, when X 1 represents a Met residue, X 7 represents a Ser residue or is null, and X 8 is null. The invention also provides a method for purifying or analyzing human IgA using such peptide.