发明名称 |
METHOD FOR HIGH-SPEED FLUOROMETHYLATION AND PROCESS FOR PREPARATION OF PET TRACER USING SAME |
摘要 |
Provided are: a method for rapid fluoromethylation, by which a fluoromethyl group can be easily bonded to an aromatic-ring carbon of an aromatic compound with little generation of by-products; and a process for preparation of a PET tracer using the same. The method is characterized by cross-coupling an organoboron compound in which an aromatic ring is bonded to a boron atom with FCX 2 Br (wherein X is ordinary hydrogen or heavy hydrogen) in a solvent obtained by adding water to an aprotic polar solvent, in the presence of a palladium complex, a phosphine ligand, and a base. |
申请公布号 |
EP2508505(B1) |
申请公布日期 |
2014.10.08 |
申请号 |
EP20100834631 |
申请日期 |
2010.12.03 |
申请人 |
RIKEN |
发明人 |
SUZUKI, MASAAKI;DOI, HISASHI;GOTO, MIKI |
分类号 |
C07C67/343;A61K51/00;C07B59/00;C07B61/00;C07C69/76;C07D311/30;G01T1/161 |
主分类号 |
C07C67/343 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|