| 摘要 |
PURPOSE: A manufacturing method of 4-alkyl-5-aryl 5-membered ring sulfamidates is provided to selectively obtain 4-alkyl-5-aryl 5-membered ring sulfamidates stereoisomeric compounds having a high optical purity and to manufacture the compounds in a simple and efficient manner. CONSTITUTION: A selective manufacturing method of a stereoisomeric compound represented by Formula 1a or 1b having optical activity allows a 4-alkyl-5-aryl 5-membered ring imine compound represented by Formula 2 to react with a hydrogen donor in presence of a chiral organometallic catalyst. The compound of Formula 1a is prepared by using a compound represented by Formula 3a as a chiral organometallic catalyst. The compound of Formula 1b is prepared by using a compound represented by Formula 3b as a chiral organometallic catalyst. The chiral organometallic catalyst of Formula 3a or 3b comprises 1 to 2 equivalents of hydrochloric acid/tri(C1-C6)alkylamine salt, hydrochloric acid/(C3-C8)cyclicalkylamine salt, and hydrochloric acid/(C5-C12)heteroaryl amine salt. |
