发明名称 |
Combination therapy comprising SGLT inhibitors and DPP4 inhibitors |
摘要 |
The present invention relates to combination therapy comprising a DPP4 inhibitor and an SGLT inhibitor. The combination of the present invention leads to increase plasma GLP-1 level and the combination is useful for prevention or treatment of conditions such as diabetes and diseases related to diabetes. |
申请公布号 |
US8853385(B2) |
申请公布日期 |
2014.10.07 |
申请号 |
US200912863429 |
申请日期 |
2009.01.16 |
申请人 |
Mitsubishi Tanabe Pharma Corporation |
发明人 |
Ueta Kiichiro;Arakawa Kenji;Matsushita Yasuaki |
分类号 |
C07H7/04 |
主分类号 |
C07H7/04 |
代理机构 |
Birch, Stewart, Kolasch & Birch, LLP |
代理人 |
Birch, Stewart, Kolasch & Birch, LLP |
主权项 |
1. A method for increasing plasma active GLP-1 level comprising administering to a patient a therapeutically effective amount of an SGLT inhibitor and a DPP4 inhibitor, wherein the SGLT inhibitor is a compound selected from the group consisting of:
1-(β-D-Glucopyranosyl)-4-chloro-3-[5-(6-fluoro-2-pyridyl)-2-thienylmethyl]benzene or a pharmaceutically acceptable salt thereof; 1-(β-D-Glucopyranosyl)-4-chloro-3-[5-(6-fluoro-3-pyridyl)-2-thienylmethyl]benzene or a pharmaceutically acceptable salt thereof; 3-(4-Cyclopropylphenylmethyl)-4-fluoro-1-(β-D-glucopyranosyl)indole or a pharmaceutically acceptable salt thereof; and 3-(4 Cyclopropylphenylmethyl)-4,6-difluoro-1-(β-D-glucopyranosyl)indole or a pharmaceutically acceptable salt thereof and; the DPP4 inhibitor is a compound selected from the group consisting of: 3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl]piperazin-1-yl]pyrrolidin-2-ylcarbonyl)thiazolidine or a pharmaceutically acceptable salt thereof; Sitagliptin or a pharmaceutically acceptable salt thereof; and (2S)-2-cyano-1-[trans-4-(dimethylaminocarbonyl)cyclohexylamino]acetylpyrrolidine or a pharmaceutically acceptable salt thereof. |
地址 |
Osaka-shi JP |