发明名称 |
Polynucleotides that home to atherosclerotic plaque |
摘要 |
Described herein are homing polypeptides that home to atherosclerotic plaque(s) in mammals and nucleic acids that encode such polypeptides. Also described are methods for detecting and treating conditions or disorders associated with, or characterized, by elevated levels of homing polypeptides that home to atherosclerotic plaque and/or vulnerable plaque. |
申请公布号 |
US8853378(B2) |
申请公布日期 |
2014.10.07 |
申请号 |
US201013500801 |
申请日期 |
2010.10.09 |
申请人 |
Georgetown University;MedStar Health Research Institute, Inc. |
发明人 |
Wellstein Anton;Epstein Stephen E.;Burnett Mary Susan |
分类号 |
C07H21/04;C07K14/47;C12Q1/68 |
主分类号 |
C07H21/04 |
代理机构 |
Wolf, Greenfield & Sacks, P.C. |
代理人 |
Wolf, Greenfield & Sacks, P.C. |
主权项 |
1. A complementary DNA (cDNA) encoding a homing polypeptide, wherein the cDNA comprises the nucleotide sequence as set forth in SEQ ID NO: 24, SEQ ID NO: 25, SEQ ID NO: 26, SEQ ID NO: 27, SEQ ID NO: 28, SEQ ID NO: 29, SEQ ID NO: 30, SEQ ID NO: 31, SEQ ID NO: 32, SEQ ID NO: 33, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 36 or SEQ ID NO: 37. |
地址 |
Washington DC US |