Ester pro-drugs of [3-(1-(1H-imidazol-4-YL)ethyl)-2-methylphenyl] methanol for treating retinal diseases

摘要

The present invention relates to method of treating retinal diseases in a subject in need of such treatment, which comprises administering a therapeutically effective amount of a composition comprising a ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl]methanol, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

主权项

1. A method of treating retinal diseases, selected from dry macular degeneration and geographic atrophy, in a subject in need of such treatment, which comprises administering a pharmaceutical composition comprising a therapeutically effective amount of a compound having Formula I, its individual enantiomers, its individual tautomers or a pharmaceutically acceptable salt thereof,
thereof, wherein R1 is H or C1-3 alkyl; R2 is H or C1-3 alkyl; R3 is H, C1-10 alkyl, heterocycle or aryl; and R is C1-10 alkyl, heterocycle or aryl.