Compounds and compositions for cognition-enhancement, methods of making, and methods of treating

摘要

Disclosed are muscarinic agonist compounds including oxadiazole derivatives, compositions and preparations thereof. Also disclosed are methods of synthesizing such oxadiazole compounds. Further disclosed are methods for treating a subject with said muscarinic agonists or a pharmaceutically suitable form thereof to enhance cognitive function.

主权项

1. A compound of Formula XI:wherein
R1 is selected from the group consisting of —CR2R3R4, R2, R3 and R4 are independently selected from D or F; and R5, R6, R7, R8, and R10 are independently selected from H, D, F or a methyl group; provided that not more than one of R5, R6, R7, R8, R9, and R10 is a methyl group;and pharmaceutically acceptable salts or stereoisomers thereof.