发明名称 |
Compounds useful as inhibitors of ATR kinase |
摘要 |
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.;The compounds of this invention have formula I:;
wherein the variables are as defined herein. |
申请公布号 |
US8853217(B2) |
申请公布日期 |
2014.10.07 |
申请号 |
US201213631727 |
申请日期 |
2012.09.28 |
申请人 |
Vertex Pharmaceuticals Incorporated |
发明人 |
Charrier Jean-Damien;Storck Pierre-Henri;Studley John;Pierard Francoise Yvonne Theodora Marie |
分类号 |
A61K31/4965;A61K38/00;A61P35/00;C12P15/00;G01N33/53;A61K31/497;C07D413/14;A61K45/06 |
主分类号 |
A61K31/4965 |
代理机构 |
|
代理人 |
Che Jennifer G. |
主权项 |
1. A compound of formula I:or a pharmaceutically acceptable salt thereof. |
地址 |
Boston MA US |