Boron containing small molecules

摘要

This invention provides novel compounds, methods of using the compounds, and pharmaceutical formulations comprising the compounds.

主权项

1. A compound having a structure of formula (I):wherein
Y is hydrogen, fluoro, chloro, or bromo; R1 is phenyl substituted 2-4 times, said substitutions comprising i) 1-4 substitutions with the same or different of halo, and 0-1 substitutions with methyl, difluoromethyl, trifluoromethyl, methoxy, trifluormethoxy, or trifluoroethoxy, or ii) 2 trifluoromethyl groups; R2 is methyl, fluoromethyl, trifluoromethyl, or perfluoroethyl; R3a and R3b are independently selected from hydrogen, methyl, ethyl, or fluoromethyl, or R3a and R3b combine with the carbon to which they are attached to form a cyclopentyl ring or a cyclohexyl ring;or a salt thereof.