| 发明名称 | Fibronectin based scaffold domain proteins that bind to myostatin | ||
| 摘要 | The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins. | ||
| 申请公布号 | US8853154(B2) | 申请公布日期 | 2014.10.07 |
| 申请号 | US201314025307 | 申请日期 | 2013.09.12 |
| 申请人 | Bristol-Myers Squibb Company | 发明人 | Cload Sharon;Engle Linda;Lipovsek Dasa;Madireddi Malavi;Rakestraw Ginger Chao;Swain Joanna;Zhao Wenjun;Wei Hui;Yamniuk Aaron P.;Ramamurthy Vidhyashankar;Kozhich Alexander T.;Corbett Martin J.;Krystek, Jr. Stanley Richard |
| 分类号 | A61K38/00;A61P3/04;A61K38/28;A61P5/50;A61P3/10;A61P7/12;A61P35/00;C07K1/00;C07K14/00;C07K16/00;C07K17/00;C07H21/04;G01N33/00;C12N1/20;C12N1/00;C12P21/06;C12N15/00;C12N5/07;C12N5/10;C12N5/071;G01N33/566;A61K45/06;C07K14/435;A61K38/39;C07K16/46;G01N33/74;A61K47/48;C07K14/78 | 主分类号 | A61K38/00 |
| 代理机构 | Nelson Mullins Riley & Scarborough LLP | 代理人 | Nelson Mullins Riley & Scarborough LLP ;Remillard, Esq. Jane E.;Kanik Cynthia L. |
| 主权项 | 1. A polypeptide comprising a fibronectin type III tenth (10Fn3) domain which binds to myostatin and comprises AB, BC, CD, DE, EF, and FG loops, wherein the BC, DE, and FG loops comprise the amino acid sequences of SEQ ID NOs: 34, 39, and 75, respectively. | ||
| 地址 | Princeton NJ US | ||