Nitrogenous-ring acylguanidine derivative

摘要

[Object] An excellent agent for preventing or treating dementia, schizophrenia, and the like, based on serotonin 5-HT5A receptor modulating action, is provided.;[Means for Solution] It was confirmed that acylguanidine derivatives (the following formula I; any one of Z1, Z2, Z3, Z4 and Z5 is nitrogen atom, and the others are carbon atoms) which have the characteristic structure in which the guanidine is bonded to one ring of the quinoline or isoquinoline via a carbonyl group, and a cyclic group is bonded to the other ring, exhibit potent 5-HT5A receptor modulating actions and excellent pharmacological actions based on the 5-HT5A receptor modulating action, and thus can be excellent agents for preventing or treating dementia, schizophrenia, bipolar disorder, or attention deficit hyperactivity disorder. Thus, the present invention has been completed.;

主权项

1. A compound of formula (I) or a pharmaceutically acceptable salt thereof: (wherein the symbols have the following meanings:  : aryl, cycloalkyl, cycloalkenyl or monocyclic nitrogen-containing heterocyclic group, Z1, Z2, Z3, Z4 and Z5: one of any of them is a nitrogen atom, and the others are carbon atoms, in which the nitrogen atom is optionally oxidized to form an N-oxide, R1, R2 and R3: each independently represents H, lower alkyl, halogen, halogeno-lower alkyl, —CN, —NO2, —ORa, —S-lower alkyl, —O-halogeno-lower alkyl, —CO2Ra, —C(O)NRbRc, —SO2-lower alkyl, or -lower alkylene-ORa, R4, R5 and R6: each independently represents H, lower alkyl, cycloalkyl, halogen, halogeno-lower alkyl, —CN, —NO2, —ORa, —SO2-lower alkyl, —O-halogeno-lower alkyl, —CO2Ra, —C(O)NRbRc, —SO2-lower alkyl, or lower alkylene-ORa, Ra, Rb and Rc: each independently represents H or lower alkyl, and R7 and R8: each independently represents H or lower alkyl).