发明名称 Agents for treating disorders involving modulation of ryanodine receptors
摘要 The present invention relates to 1,4-benzothiazepine derivatives and their use to treat conditions, disorders and diseases associated with ryanodine receptors (RyRs) that regulate calcium channel functioning in cells. The invention also discloses pharmaceutical compositions comprising the compounds and uses thereof to treat diseases and conditions associated with RyRs, in particular cardiac, musculoskeletal and central nervous system (CNS) disorders.
申请公布号 US8853198(B2) 申请公布日期 2014.10.07
申请号 US201314076474 申请日期 2013.11.11
申请人 Les Laboratoires Servier;ARMGO Pharma, Inc. 发明人 Yan Jiaming;Belvedere Sandro;Webb Yael;Bertrand Marc;Villeneuve Nicole
分类号 A61K31/554;C07D281/10;A61K31/7088;C07D285/36 主分类号 A61K31/554
代理机构 Hueschen and Sage 代理人 Hueschen and Sage
主权项 1. A compound represented by the structure of Formula (I): wherein R is COOH; and pharmaceutically acceptable salts thereof.
地址 Suresnes Cedex FR