Compositions and methods for modifying cell surface glycans

摘要

Methods and compositions for modifying glycans (e.g., glycans expressed on the surface of live cells or cell particles) are provided herein.

主权项

1. A composition comprising a population of isolated mesenchymal stem cells (MSCs) having E-selectin binding activity, wherein the population is produced by α-1,3-fucosylation of the MSCs ex vivo in a physiologically acceptable solution to form the population, the population having fucosylated glycan structures on the surfaces thereof and a viability of at least 70% at 24 hours after the α-1,3-fucosylation of the MSCs.