Endokinin C/D-derived peptides

摘要

The present invention provides peptides capable of sustaining antagonist activity against substance P for long periods of time. A peptide selected from (a) to (d) can sustain antagonist activity against substance P, analgesic activity, and anti-inflammation activity for a long period of time:;(SEQ ID NO: 3)(a) Ala-Tyr-Gln-Leu-Glu-His-Thr-DTrp-Gln-Gly-Leu-Leu-NH2;(b) a peptide consisting of a partial sequence of (a), which consists of 6 to 11 consecutive amino acids comprising at least the C-terminal Thr-DTrp-Gln-Gly-Leu-Leu-NH2 (SEQ ID NO: 18);(c) Ala-Tyr-Gln-Leu-Glu-His-Thr-Phe-Gln-DTrp-Leu-Leu-NH2 (SEQ ID NO: 4); and(d) a peptide consisting of a partial sequence of (c), which consists of 6 to 11 consecutive amino acids comprising at least the C-terminal Thr-Phe-Gln-DTrp-Leu-Leu-NH2 (SEQ ID NO: 8).

主权项

1. A peptide selected from the group consisting of:
(a) an amino acid sequence represented by Ala-Tyr-Gln-Leu-Glu-His-Thr-Phe-Gln-DTrp-Leu-Leu-NH2 (SEQ ID NO: 4); (b) a partial sequence of SEQ ID NO: 4 consisting of 6 to 11 consecutive amino acids including at least the C-terminal Thr-Phe-Gln-DTrp-Leu-Leu-NH2 (SEQ ID NO: 8); and (c) an amino acid sequence consisting of sequence (a) or (b), modified with either a deletion of a single amino acid, a substitution of a single amino acid, or an addition of from 1 to 5 amino acids at a position other than DTrp and C-terminal Leu-NH2, wherein the modified amino acid sequence of (a) or (b) excludes an amino acid sequence where Phe is substituted with DTrp.