Humanized anti-IL-10 antibodies for the treatment of systemic lupus erythematosus (SLE)

摘要

Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (Th-10), wherein said antibody or fragment thereof is capable of being administered to a subject in the absence of an intolerable increase in the level of pro-inflammatory cytokines. Further provided are methods of treatment involving the use of the antibody or fragment thereof.

主权项

1. An in vitro method for neutralizing interleukin-10 in a sample, comprising a step of contacting the sample with an antibody or fragment thereof capable of binding interleukin-10, so as to bind the antibody or fragment thereof to the interleukin-10, wherein the antibody or fragment thereof comprises a variable light chain comprising the amino acid sequences SEQ ID NO: 71, 72 and 73, and a variable heavy chain comprising the amino acid sequences SEQ ID NO: 74, 75 and 76.