Self-assembled toroidal-spiral particles and manufacture and uses thereof

摘要

Toroidal-spiral shaped particles, their method of manufacture, and uses thereof are disclosed. The toroidal-spiral particles can contain at least one active agent, such as a drug, and provide a controlled, sustained release of the active agent.

主权项

1. A method of manufacturing a particle delivery system comprising polymeric toroidal-spiral particles having at least one active agent incorporated therein comprising:
(a) providing a polymer solution or a polymer melt; (b) providing a bulk phase solution containing at least one active agent, wherein the polymer solution or the polymer melt is soluble in the bulk phase solution; (c) introducing at least one drop of (a) at a surface of (b) and allowing the drop to pass through (b) at a rate wherein the drop attains a toroidal-spiral shape and wherein the at least one active agent is loaded onto the toroidal-spiral shaped polymer drop; and (d) crosslinking the toroidal-spiral shaped polymer drop of (c) to form a solid polymeric particle having the at least one active agent incorporated therein.