| 发明名称 | Universal carrier for targeting molecules to Gb3 receptor expressing cells | ||
| 摘要 | The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein: STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z is an amino-acid devoided of sulfhydryl group, n being 0, 1 or a polypeptide,Cys is the amino-acid Cysteine, and the use thereof for MHC class I and MHC class II presentation of antigens. | ||
| 申请公布号 | US8852612(B2) | 申请公布日期 | 2014.10.07 |
| 申请号 | US200912569007 | 申请日期 | 2009.09.29 |
| 申请人 | Institute Curie;Centre National de la Recherche Scientifique;Institut National de la Sante et de la Recherche Medicale;Universite Pierre et Marie Curie (Paris VI) | 发明人 | Johannes Ludger;Tartour Eric;Goud Bruno;Fridman Wolf Herve |
| 分类号 | A61K39/02;A61K45/00;A61K47/00;C12P21/06;C12N1/20;C12N15/00;C12N5/00;C12N5/02;A61K39/385;C07K14/25;A61K48/00;A61K39/00;A61K38/00 | 主分类号 | A61K39/02 |
| 代理机构 | Birch, Stewart, Kolasch & Birch, LLP | 代理人 | Birch, Stewart, Kolasch & Birch, LLP |
| 主权项 | 1. A method for delivering a sequence of interest into the MHC class I and MHC class II pathways said method comprising: administering a universal polypeptidic carrier and having the following formula STxB-Z(n)-Cys, wherein: STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z is an amino acid devoid of a sulfhydryl group, n being, 0, 1 or a polypeptide, Cys is the amino acid cysteine, wherein said sequence of interest is bound to said universal polypeptidic carrier via the Cys moiety, wherein said universal polypeptide binds to Gb3 receptor expressing cells, while maintaining universal polypeptide conformation and enters into the MHC class I and MHC class II pathways. | ||
| 地址 | Paris Cedex FR | ||