Compositions and methods for preferential distribution of active agents to injury sites

摘要

Compositions are provided for preferential distribution of active agents to injury sites. Such compositions may comprise a ligand with hydrophilic properties and one or more active agents, such as compounds comprising hydrophilic metal ions. Because the delivery ligand and the active agent are specifically selected so the interactions between them are mainly of an ionic nature so that binding of the active agent to the delivery ligand and release of the active agent into the target site are not dependent on enzymatic activity. Methods of using such compositions are also disclosed.

主权项

1. A method of increasing magnesium at a site of a spinal cord injury in a patient, the method comprising administering to the patient a composition comprising a delivery ligand comprising polyethylene glycol (PEG) having a molecular weight of between about 100 DA and about 20,000 DA and the polyethylene glycol comprises at least 30% weight per volume of the composition and the composition comprises about 0.4% to about 4% weight per volume of magnesium, and at least one dose of the composition is administered within one half-life of the delivery ligand wherein the half-life of the ligand is between about 30 and about 90 minutes.