| 发明名称 | Extracellular matrix compositions for the treatment of cancer | ||
| 摘要 | The present invention is directed to methods of inhibiting cancer cell growth or proliferation by contacting the cancer cell with an extracellular matrix (ECM) composition. Also provided are methods of delivering a chemotherapeutic agent to a cancer cell by contacting a cancer cell with an extracellular matrix composition containing a chemotherapeutic agent. Also provided are compositions containing ECM and a chemotherapeutic agent. | ||
| 申请公布号 | US8852637(B2) | 申请公布日期 | 2014.10.07 |
| 申请号 | US200912363479 | 申请日期 | 2009.01.30 |
| 申请人 | Histogen, Inc. | 发明人 | Naughton Gail K.;Pinney Emmett |
| 分类号 | C12N5/00;A61K35/12;A61K31/282;A61K9/14 | 主分类号 | C12N5/00 |
| 代理机构 | DLA Piper LLP (US) | 代理人 | DLA Piper LLP (US) |
| 主权项 | 1. A method of inhibiting cancer cell growth or proliferation in vivo, comprising contacting a cancer cell with an extracellular matrix (ECM) composition produced by culturing human fibroblast cells on microcarrier beads under hypoxic conditions of 1-5% oxygen to produce a hypoxic extracelluar matrix and collecting the hypoxic ECM, thereby inhibiting cancer cell growth or proliferation. | ||
| 地址 | San Diego CA US | ||