Biomedical implants comprising surface-modified ceramic particles and biodegradable stereo complex polymers, its use for suppressing inflammation and improvement of mechanical property, and preparation method thereof

摘要

A biomedical implant according to this invention comprises ceramic complex, which includes a surface-modified basic ceramic particles, which are basic ceramic particles modified their surface with first biodegradable polymers, and the second biodegradable polymers. The first and second biodegradable polymer are combined each other and form a stereo complex. The biomedical implant has a superior effect to suppress inflammation caused by degradation of biodegradable polymers with improving its mechanical property.

主权项

1. A biomedical implant comprising a ceramic complex, wherein the ceramic complex comprises:
surface-modified basic ceramic particles, which are basic ceramic particles with their surface modified with first biodegradable polymers; and second biodegradable polymers, which are combined with the first biodegradable polymers to form a stereo complex; wherein the content of the first biodegradable polymers and the second biodegradable polymers is 5 to 95 wt % and the content of basic ceramic particles is 5 to 95 wt % with respect to the total weight of the ceramic complex, wherein the surface-modified basic ceramic particles form a core-shell structure in which the basic ceramic particles are a core and the first biodegradable polymers are a shell, and wherein the surface-modified basic ceramic particles are in the matrix of the stereo complex.