| 发明名称 | Synthetic glycolipid and use thereof | ||
| 摘要 | A compound represented by the following formula (1):; wherein R1 is an aldopyranose residue wherein the 6-hydroxyl group is optionally alkylated, R2 is a C1-26 hydrocarbon group optionally having substituent(s), R3 is a hydrogen atom or a C1-26 hydrocarbon group optionally having substituent(s), R4 is a C1-21 hydrocarbon group optionally having substituent(s), X is an oxygen atom or —CH2—, and Y is —CH2—, —CH(OH)— or —CH═CH—, or a salt thereof is useful for the prophylaxis or treatment of cancer or infection, since it can preferentially induce production of IFN-γ of NKT cells. | ||
| 申请公布号 | US8853173(B2) | 申请公布日期 | 2014.10.07 |
| 申请号 | US201113577159 | 申请日期 | 2011.02.04 |
| 申请人 | RIKEN | 发明人 | Tashiro Takuya;Mori Kenji;Shiozaki Masao;Taniguchi Masaru;Watarai Hiroshi |
| 分类号 | C07H17/02;A61K31/7028;A61P31/04;A61K31/7032;C07H15/04 | 主分类号 | C07H17/02 |
| 代理机构 | Leydig, Voit & Mayer, Ltd. | 代理人 | Leydig, Voit & Mayer, Ltd. |
| 主权项 | 1. A compound represented by the formula (1) or a salt thereof: wherein R1 is an aldopyranose residue wherein the 6-hydroxyl group is optionally alkylated, R2 is a C1-26 hydrocarbon group optionally having substituent(s), R3 is a hydrogen atom or a C1-26 hydrocarbon group optionally having substituent(s), R4 is a C1-21 hydrocarbon group optionally having substituent(s), X is an oxygen atom or —CH2—, and Y is —CH2—, —CH(OH)— or —CH═CH—. | ||
| 地址 | Wako JP | ||