| 发明名称 |
Treatment for diabetes in patients inappropriate for metformin therapy |
| 摘要 |
The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing metabolic diseases, particularly diabetes, in patients for whom metformin therapy is inappropriate due to intolerability or contraindication against metformin. |
| 申请公布号 |
US8853156(B2) |
申请公布日期 |
2014.10.07 |
| 申请号 |
US200913057295 |
申请日期 |
2009.08.05 |
| 申请人 |
Boehringer Ingelheim International GmbH |
发明人 |
Dugi Klaus;Graefe-Mody Eva Ulrike;Harper Ruth;Woerle Hans-Juergen |
| 分类号 |
A61K38/00;A61K38/28;A61P3/10;A61P7/12;C07K14/62;A01N43/58;A01N43/60;A61K31/50;A61K31/495;A61K31/52;A61K31/513;A61K31/4375;A61K31/4439;A61K31/427;A61K31/422;A61K31/403;A61K31/4025;A61K31/40;A61K31/506;A61K31/4985;A61K31/522;A61K31/5025 |
主分类号 |
A61K38/00 |
| 代理机构 |
|
代理人 |
Morris Michael P.;Kershner David L. |
| 主权项 |
1. A method of treating and/or preventing metabolic diseases in a patient for whom metformin therapy is inappropriate due to at least one contraindication against metformin comprising orally administering to the patient a DPP-IV inhibitor wherein the contraindication is selected from the group consisting of:
renal disease, renal impairment or renal dysfunction, unstable or acute congestive heart failure, acute or chronic metabolic acidosis, and hereditary galactose intolerance. |
| 地址 |
Ingelheim am Rhein DE |
