| 主权项 |
1. A compound of Formula (VI), or a pharmaceutically acceptable salt, or solvate thereof: wherein, R1 is H, F, C1-C6alkyl, or C1-C6fluoroalkyl; is azetidinyl or pyrrolidinyl; each R4 is independently selected from F, Cl, —OH, —CH3, —CF3, —OCF3 and —OCH3; each R5 is independently selected from halogen, —CN, —OH, —OR7, substituted or unsubstituted C1-C6alkyl, and substituted or unsubstituted C1-C6fluoroalkyl; each R6 is independently selected from halogen, —CN, —OH, —OR7, —SR7, —S(═O)R8, —S(═O)2R8, —NHS(═O)2R8, substituted or unsubstituted C1-C6alkyl, and substituted or unsubstituted C1-C6fluoroalkyl; each R7 is independently selected from H, —C(═O)R8, —C(═O)OR8, —C(═O)NHR8, C1-C6alkyl, C1-C6heteroalkyl, or C1-C6fluoroalkyl; R8 is independently selected from C1-C6alkyl, C1-C6heteroalkyl, or C1-C6fluoroalkyl; each R9 is independently selected from F, Cl, —OH, C1-C4alkyl, C1-C4fluoroalkyl, C1-C4fluoroalkoxy, C1-C4alkoxy, and C1-C4heteroalkyl; each R10 is independently H, F, or C1-C4alkyl; or both R10 are taken together with the carbon atom to which they are attached to form —C(═O)—; X is —O—; m is 0, or 1; n is 0, 1, or 2; p is 0, 1, 2, or 3; t is 1, or 2; wherein substituted groups are substituted with one or more groups selected from halogen, —CN, —NH2, —OH, —NH(CH3), —N(CH3)2, —CH3, —CH2CH3, —CF3, —OCH3, and —OCF3. |
