| 摘要 |
Anti-herpetic material such as 2-aminopurine derivatives, e.g., the aminocyclopropylcarboxylate derivatives of acyclovir, penciclovir, and ganciclovir, are described to prevent or treat autoimmune disease or a disease originating from an abnormal functioning of the sympathetic chain in a human subject. Prolonged use of the anti-herpetic compounds reduces prodrome, vesicle formation and viral shedding. The anti-herpetic compounds may be administered alone or in combination with a compound that reduces the rate of renal excretion of the anti-herpetic compound. The anti-herpetic compounds are particularly useful when administered at a level equivalent in activity to at—least about 150 mg/kg famciclovir per day. |
| 主权项 |
1. A compound of the formula
1.wherein A is CH2 [or O];B is H, Cl, alkoxy of 1-6 carbon atoms, phenoxy, phenylalkoxy where alkoxy is 1-6 carbon atoms, NH2, OH or SH;R1 is
2. wherein n is 1 and R3 is H or alkyl of 1-4 carbon atoms; and R2 is independently H, C(O)R5 where R5 is alkyl of 1-5 carbon atoms, C(O)CH(NH2)R4 where R4 is H or alkyl of 1-4 carbon atoms, proline, hydroxyproline, or 3.wherein n and R3 are as defined above,or a pharmaceutically acceptable salt thereof. |
