Cardiac muscle regeneration using mesenchymal stem cells

摘要

Disclosed is a method for producing cardiomyocytes in vivo by administering to the heart of an individual a cardiomyocyte producing amount of mesenchymal stem cells. These cells can be administered as a liquid injectible or as a preparation of cells in a matrix which is or becomes solid or semi-solid. The cells can be genetically modified to enhance myocardial differentiation and integration. Also disclosed is a method for replacing cells ex vivo in a heart valve for implantation.

主权项

1. A method for treating a patient with myocardial infarction comprising:
administering to the patient human allogeneic mesenchymal stem cells in an amount effective to improve cardiac function following myocardial infarction.