发明名称 SILYL DERIVATIVE OF NOVEL PYRIMIDINE NUCLEOSIDE
摘要 <p>PROBLEM TO BE SOLVED: To provide a novel pyrimidine nucleoside compound exhibiting more excellent balance of antitumor effect and toxicity than that of existing pyrimidine nucleoside compounds.SOLUTION: The compound is represented by the general formula (1): [in the formula, one of A1 and A2 is a hydrogen atom or a group represented by (R1)(R2)(R3)Si- and the other is a group represented by (R4)(R5)(R6)Si-, or A1 and A2 are taken together to form a cyclic group represented by -(R7)(R8)Si- or -(R9)(R10)Si-O-Si(R11)(R12)-; R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 each represents an alkyl group having a carbon number of 1 to 12 which may have a substituent group or an aryl group having a carbon number of 6 to 14 which may have a substituent group].</p>
申请公布号 JP2014189499(A) 申请公布日期 2014.10.06
申请号 JP20130064235 申请日期 2013.03.26
申请人 TAIHO YAKUHIN KOGYO KK 发明人 TANAKA YUKI;NOMURA MAKOTO;KAZUNO YUMI;OGUCHI KEI
分类号 C07H19/06;A61K31/7072;A61P35/00;C07F7/18 主分类号 C07H19/06
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