Methods and compositions for treating cancers having acquired resitance to prior chemotherapeutic and targeted drugs using carboxyamidotriazole orotate

摘要

This invention provides methods and compositions useful for treating early and late stage metastatic cancer to prevent or treat acquired resistance due to gene amplification or mutation in response to chemotherapeutic and/or targeted drugs. In particular, the methods and compositions include carboxiamidotriazole orotate (CTO) alone or in combination with specific regimens of chemotherapeutic and/or targeted drugs designed to overcome the genomic resistance raised to prior therapy.

主权项

1. A method of preventing or overcoming acquired resistance due to gene amplification or mutation in response to chemotherapeutic and targeted drugs, said method comprising administering an effective amount of carboxyamidotriazole orotate in the range 50 mg/m2 to 1500 mg/m2 based on the patient's body surface.