| 主权项 |
1. A compound of Formula I-A:or its pharmaceutically acceptable salts thereof, wherein
W1 is N or CR5, W2 is N or CR6, W3 is N or CR7, W4 is N or CR8, wherein no more than two N atoms are adjacent; R1 is -(L)n-R1′; L is —S—, —N(R2)—, —C(R3)2—, or —O—; n is 0 or 1; R1′ is hydrogen, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocycloalkyloxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, cyano, hydroxy, nitro, phosphate, urea, carbonate, or NR′R″ wherein R′ and R″ are taken together with nitrogen to form a cyclic moiety; R4, R5, R6, R7 and R8 are independently hydrogen, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocycloalkyloxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, cyano, hydroxy, nitro, phosphate, urea, carbonate, or NR′R″ wherein R′ and R″ are taken together with nitrogen to form a cyclic moiety; X is absent or is —(CH(R10))z and z is an integer of 1, 2, 3, or 4; Y is absent, —O—, —S—, —S(═O)—, —S(═O)2—, —N(R9)—, —C(═O)—(CHR10)z—, —C(═O)—, —N(R9)—C(═O)—, or —N(R9)—C(═O)NH—, —N(R9)C(R10)2—, or —C(═O)—(CHR10)z—; each instance of R2 and R9 is independently hydrogen, C1-C10alkyl, C3-C7cycloalkyl, heterocycloalkyl, C2-C10heteroalkyl, aryl, or heteroaryl; each instance of R3 and R10 is independently hydrogen, alkyl, aryl, heteroaryl or halo; and Wd is heterocycloalkyl, aryl, cycloalkyl, or heteroaryl. |
