| 发明名称 |
Radiation-Sterilized Biodegradable Drug Delivery Composition |
| 摘要 |
The present disclosure is directed to a method of making a composition by combining a vehicle, e.g., a single phase vehicle, and an insoluble component comprising a beneficial agent, and sterilizing the composition using ionizing radiation prior to use, wherein the beneficial agent is stable following exposure to a sterilizing dose of ionizing radiation. Related compositions and methods are provided. |
| 申请公布号 |
US2014294977(A1) |
申请公布日期 |
2014.10.02 |
| 申请号 |
US201214360297 |
申请日期 |
2012.11.21 |
| 申请人 |
DURECT CORPORATION |
发明人 |
Sekar Michael;Yum Su Il;Theeuwes Felix;van Osdol William |
| 分类号 |
C07K14/61;A61K38/17;A61K38/27;A61K38/22;A61K31/198;C07K14/575 |
主分类号 |
C07K14/61 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition, comprising:
a single-phase vehicle, comprising:
a biodegradable polymer in an amount ranging from about 5% to about 40% by weight of the vehicle, anda hydrophobic solvent in an amount ranging from about 95% to about 60% by weight of the vehicle; and an insoluble beneficial agent complex comprising a beneficial agent in the vehicle,
wherein the composition has been irradiated with ionizing radiation, and wherein the beneficial agent is present at a purity of about 90% or greater. |
| 地址 |
Cupertino CA US |
