METHODS OF TREATING A TAUOPATHY

摘要

The present disclosure provides methods of treating a tauopathy, involving administering an anti-Tau antibody. The present disclosure also provides anti-Tau antibodies, and formulations comprising same, for use in the methods.

主权项

1. A pharmaceutical composition comprising:
a) a pharmaceutically acceptable excipient suitable for administration to a human; and b) a humanized antibody that specifically binds an epitope within an N-terminal portion of a human Tau polypeptide, wherein the humanized antibody comprises:
(i) a VL CDR1 comprising the amino acid sequence of SEQ ID NO:1;(ii) a VL CDR2 comprising the amino acid sequence of SEQ ID NO:2;(iii) a VL CDR3 comprising the amino acid sequence of SEQ ID NO:3;(iv) a VH CDR1 comprising the amino acid sequence of SEQ ID NO:4;(v) a VH CDR2 comprising the amino acid sequence of SEQ ID NO:5; and(vi) a VH CDR3 comprising the amino acid sequence of SEQ ID NO:6 or
(i) a VL CDR1 comprising the amino acid sequence of SEQ ID NO:7;(ii) a VL CDR2 comprising the amino acid sequence of SEQ ID NO:8;(iii) a VL CDR3 comprising the amino acid sequence of SEQ ID NO:9;(iv) a VH CDR1 comprising the amino acid sequence of SEQ ID NO:10;(v) a VH CDR2 comprising the amino acid sequence of SEQ ID NO:11; and(vi) a VH CDR3 comprising the amino acid sequence of SEQ ID NO:12.