METHODS AND COMPOSITIONS TO REDUCE SERUM LEVELS OF TRIACYLGLYCERIDES IN HUMAN BEINGS USING A FUNGAL LIPASE

摘要

The invention relates to methods and compositions for reducing serum levels of triacylglycerides in human subjects. In particular, the invention relates to the oral administration of an effective amount of a fungal lipase formulation, to a human subject having borderline-high or high serum levels of triacylglycerides, for a time period sufficient to reduce serum triacylglyceride levels.

主权项

1. A method of reducing serum triacylglyceride levels in a human subject comprising, administering a composition comprising an effective amount of a fungal lipase that (i) exhibits at least 50% of its maximum activity over the pH range of 2.0 to 8.0; and (ii) cleaves all three ester sites of a triglyceride, to a human subject in need thereof, wherein the effective amount of said fungal lipase comprises at least 15,000 FIP units/meal.