| 摘要 |
Provided herein are compounds, methods and pharmaceutical compositions for use in treatment of viral infections, including hepatitis C virus (HCV) infections, in hosts in need thereof. In certain embodiments, the compounds are 2′,4′-fluoro nucleosides according to Formula 1001:;;or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein Base, RA, and PD are as described herein. In certain embodiments, 2′,4′-fluoro nucleosides are provided which display remarkable efficacy and bioavailability for the treatment of, for example, HCV infection in a human. |
| 主权项 |
1. A compound according to Formula 1001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein: Base is a nucleobase; PD is hydrogen, W is S or O; each of X and Y is independently hydrogen, —OR1, —SR1, —NR1R2, or an N-linked amino acid or ester thereof; RA is hydrogen, hydroxyl, or halo; or, in the alternative, Y and RA, together with the atoms to which they are attached, combine to form a six-membered heterocyclic ring wherein Y and RA together represent a single divalent —O—, and X is —OR1, —SR1, —NR1R2, or an N-linked amino acid or ester thereof; each R1 is independently hydrogen, alkyl, aryl, arylalkyl, cycloalkyl, heterocycloalkyl, or alkylcarbonylthioalkyl; and each R2 is independently hydrogen, alkyl, cycloalkyl, aryl, or arylalkyl. |
