RESPONSIVENESS TO ANGIOGENESIS INHIBITORS

摘要

The invention is concerned with a method of determining whether a patient is more suitably treated by a therapy with an angiogenesis inhibitor, such as bevacizumab, by determining the genotype of VEGF promoter gene and/or VEGFR2 gene. The invention further relates to a pharmaceutical composition comprising an angiogenesis inhibitor, such as bevacizumab, for the treatment of a patient suffering from cancer based on the genotype of VEGF promoter gene and/or VEGFR2 gene. The invention further relates to a method for improving the treatment effect of chemotherapy of a patient suffering from cancer by adding an angiogenesis inhibitor, such as bevacizumab, based on the genotype of VEGF promoter gene and/or VEGFR2 gene.

主权项

1. A method of determining whether a patient is suitably treated by a therapy comprising an angiogenesis inhibitor comprising bevacizumab or an antibody that binds essentially the same epitope on VEGF as bevacizurnab, said method comprising:
(a) determining in a sample derived from a patient suffering from cancer the genotype at polymorphism rs699946 (SEQ ID NO. 1), and (b) identifying a patient as more or less suitably treated by a therapy comprising an angiogenesis inhibitor comprising bevacizumab or an antibody that binds essentially the same epitope on VEGF as bevacizumab based on said genotype, wherein the presence of each A allele at polymorphism rs699946 (SEQ ID NO. 1) indicates an increased likelihood that said patient is more suitably treated, or the presence of each G allele at polymorphism rs699946 (SEQ ID NO. 1) indicates an increased likelihood that said patient is less suitably treated.