发明名称 |
NANOPARTICLE COMPOSITIONS FOR GENERATION OF REGULATORY T CELLS AND TREATMENT OF AUTOIMMUNE DISEASES AND OTHER CHRONIC INFLAMMATORY CONDITIONS |
摘要 |
The present invention relates to nanoparticles for the targeted delivery of antigen to liver cells, in particular, liver sinusoidal endothelial cells (LSEC) and/or Kupffer cells, and for the in vivo generation of regulatory T cells, notably CD4+CD25+FOXP3+ regulatory T cells (Treg). The invention provides pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, allergies or other chronic inflammatory conditions, and for generation of regulatory T cells. The nanoparticles used in the invention comprise a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising at least one T cell epitope associated with the outside of the micelle. The micelle may or may not comprise a solid hydrophobic core. |
申请公布号 |
US2014294982(A1) |
申请公布日期 |
2014.10.02 |
申请号 |
US201213261883 |
申请日期 |
2012.11.14 |
申请人 |
UNIVERSITÄTSKLINIKUM HAMBURG-EPPENDORF ;UNIVERSITÄT HAMBURG ;HEINRICH-PETTE-INSTITUT |
发明人 |
Freund Barbara;Heeren Jörg;Nielsen Peter;Carambia Antonella;Herkel Johannes;Bruns Oliver;Lohse Ansgar;Lüth Stefan;Weller Horst;Salmen Sunhild |
分类号 |
A61K9/14;A61K39/00 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
1. A pharmaceutical composition comprising a nanoparticle, said nanoparticle comprising
a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising at least one T cell epitope associated with the outside of the micelle, for use in generating regulatory T cells specific to said at least one T cell epitope in a subject. |
地址 |
Hamburg DE |