| 发明名称 |
HYPOALLERGENIC VARIANTS OF MAL D 1, THE MAJOR ALLERGEN FROM MALUS DOMESTICA |
| 摘要 |
Disclosed are hypoallergenic variants of Mal d 1, the major allergen from Malus domestica, and the uses thereof in the treatment of allergic diseases. |
| 申请公布号 |
US2014294878(A1) |
申请公布日期 |
2014.10.02 |
| 申请号 |
US201214234795 |
申请日期 |
2012.07.31 |
| 申请人 |
Mistrello Giovanni;Zanotta Stefania;Roncarolo Daniela |
发明人 |
Mistrello Giovanni;Zanotta Stefania;Roncarolo Daniela |
| 分类号 |
C07K14/415 |
主分类号 |
C07K14/415 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A sequence variant of the Malus domestica major allergen Mal d 1 wt SEQ ID NO:1 or of an isoform thereof identical to SEQ ID NO:1 by at least 95%, said variant being characterized in that:
a) it shows reduced IgE reactivity compared with said Mal d 1 allergen SEQ ID NO:1; b) it has an amino-acid sequence which, when aligned with SEQ ID NO:1, presents at least one substitution at residues Asp and/or Asn corresponding to positions 25 and 78 of SEQ ID NO:1. |
| 地址 |
Milano IT |
