Methods are disclosed for diagnosing a hyposialylation disorder. Methods are also disclosed for determining the effectiveness of a therapeutic agent for treatment of a hyposialylation disorder in a subject. These methods include measuring an amount of monosialylated Thomsen- Friedenreich (ST) antigen and measuring an amount of non-sialylated Thomsen-Friedenreich antigen (T) in a biological sample, such as a serum or plasma sample from the subject, and determining the ratio of T to ST.
申请公布号
WO2014160018(A1)
申请公布日期
2014.10.02
申请号
WO2014US25633
申请日期
2014.03.13
申请人
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;EMORY UNIVERSITY
发明人
HUIZING, MARJAN;GAHL, WILLIAM, A.;CARRILLO-CARRASCO, NURIA;HE, MIAO;LI, XUELI;JIANG, RONG