| 发明名称 |
Using RNA-guided FokI Nucleases (RFNs) to Increase Specificity for RNA-Guided Genome Editing |
| 摘要 |
Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems. |
| 申请公布号 |
US2014295556(A1) |
申请公布日期 |
2014.10.02 |
| 申请号 |
US201414213479 |
申请日期 |
2014.03.14 |
| 申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
Joung J. Keith;Tsai Shengdar |
| 分类号 |
C12N9/22;C12N15/63 |
主分类号 |
C12N9/22 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An RNA-guided FokI Nuclease (RFN) fusion protein, comprising a FokI catalytic domain sequence fused to the amino terminus of a catalytically inactive CRISPR-associated 9 (dCas9). |
| 地址 |
BOSTON MA US |
