发明名称 |
TREATING FIBROSIS AND INFLAMMATION BY INHIBITING TL1A |
摘要 |
The invention relates to methods of treating fibrosis and inflammatory bowel disease. In one embodiment, the present invention treats gut inflammation by administering a therapeutically effective dosage of TL1A inhibitors and/or DR3 inhibitors to an individual. In another embodiment, the present invention provides a method of reversing tissue fibrosis in an individual by inhibiting TL1A-DR3 signaling function. |
申请公布号 |
WO2014160883(A1) |
申请公布日期 |
2014.10.02 |
申请号 |
WO2014US32054 |
申请日期 |
2014.03.27 |
申请人 |
CEDARS-SINAI MEDICAL CENTER |
发明人 |
SHIH, DAVID Q.;TARGAN, STEPHAN R.;LI, DALIN;BILSBOROUGH, JANINE |
分类号 |
A61K38/12;A61K38/16;C12Q1/68 |
主分类号 |
A61K38/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|