发明名称 |
POTENT ANALOGUES OF THE C-MYC INHIBITOR 10074-G5 WITH IMPROVED CELL PERMEABILITY |
摘要 |
The present invention relates compounds and compositions for interfering with the association of Myc and Max. These compounds and compositions are useful in methods for inhibiting growth or proliferation of a cell. Methods of inhibiting growth or proliferation of a cell comprise contacting the cell with an amount of a compound that interferes with Myc and Max association effective to inhibit growth or proliferation of the cell. The compounds exhibit increased inhibitory activity against c-Myc relative to the known c-Myc inhibitor small-molecule benzofurazan N-([1,1′-biphenyl]-2-yl)-7-nitrobenzo[c][1,2,5]oxadiazol-4-amine (10074-G5). |
申请公布号 |
US2014296307(A1) |
申请公布日期 |
2014.10.02 |
申请号 |
US201414227243 |
申请日期 |
2014.03.27 |
申请人 |
University of Maryland, Baltimore |
发明人 |
FLETCHER STEVEN |
分类号 |
C07D271/12 |
主分类号 |
C07D271/12 |
代理机构 |
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代理人 |
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主权项 |
1. A compound represented by the formula: or a pharmaceutically acceptable salt thereof. |
地址 |
Baltimore MD US |