| 主权项 |
1. A compound of formula (I) or a pharmaceutically acceptable salt, prodrug or metabolite thereof, wherein X is O; or S; m is 1; 2; or 3; n is 1; 2; or 3; R1 is H; C(O)R3; C(O)OR3; C(O)N(R3R3a); S(O)2N(R3R3a); S(O)N(R3R3a); S(O)2R3; S(O)R3; T1; or C1-6 alkyl, wherein C1-6 alkyl is optionally substituted with one or more R4, which are the same or different; R3, R3a are independently selected from the group consisting of H; T1; and C1-6 alkyl, wherein C1-6 alkyl is optionally substituted with one or more R4, which are the same or different; R4 is halogen; CN; C(O)OR5; OR5; C(O)R5; C(O)N(R5R5a); S(O)2N(R5R5a); S(O)N(R5R5a); S(O)2R5; S(O)R5; N(R5)S(O)2N(R5R5b); N(R5)S(O)N(R5aR5b); SR5; N(R5R5a); NO2; OC(O)R5; N(R5)C(O)R5a; N(R5)S(O)2R5a; N(R5)S(O)R5a; N(R5)C(O)N(R5aR5b); N(R5)C(O)OR5a; OC(O)N(R5R5a); or T1; R5, R5a, R5b are independently selected from the group consisting of H; and C1-6 alkyl, wherein C1-6 alkyl is optionally substituted with one or more halogen, which are the same or different; T1 is C3-7cycloalkyl; 4 to 7 membered heterocyclyl; 8 to 11 membered heterobicyclyl; phenyl; naphthyl; indenyl; or indanyl, wherein T1 is optionally substituted with one or more R6, which are the same or different; R6 is halogen; CN; C(O)OR7; OR7; oxo (═O), where the ring is at least partially saturated; C(O)R7; C(O)N(R7R7a); S(O)2N(R7R7a); S(O)N(R7R7a); S(O)2R7; S(O)R7; N(R7)S(O)2N(R7aR7b); N(R7)S(O)N(R7aR7b); SR7; N(R7R7a); NO2; OC(O)R7; N(R7)C(O)R7a; N(R7)S(O)2R7a; N(R7)S(O)R7a; N(R7)C(O)N(R7aR7b); N(R7)C(O)OR7a OC(O)N(R7R7a); or C1-6 alkyl, wherein C1-6 alkyl is optionally substituted with one or more R8, which are the same or different; R7, R7a, R7b are independently selected from the group consisting of H; C1-6 alkyl, wherein C1-6 alkyl is optionally substituted with one or more halogen, which are the same or different; R8 is halogen; CN; C(O)OR9; OR9; C(O)R9; C(O)N(R9R9a); S(O)2N(R9R9a); S(O)N(R9R9a); S(O)2R9; S(O)R9; N(R9)S(O)2N(R9aR9b); N(R9)S(O)N(R9aR9b); SR9; N(R9R9a); NO2; OC(O)R9; N(R9)C(O)R9a; N(R9)S(O)2R9a; N(R9)S(O)R9a; N(R9)C(O)N(R9aR9b); N(R9)C(O)OR9a; or OC(O)N(R9R9a); R9, R9a, R9b are independently selected from the group consisting of H; and C1-6 alkyl, wherein C1-6 alkyl is optionally substituted with one or more halogen, which are the same or different; o is 1; 2; 3; or 4; Each R2 is independently selected from the group consisting of H; halogen; CN; C(O)OR10; OR10a; oxo (═O); C(O)R10; C(O)N(R10R10a); S(O)2N(R10R10a); S(O)N(R10R10a); S(O)2R10; S(O)R10; N(R10)S(O)2N(R10aR10b); N(R10)S(O)N(R10aR10b); SR10; N(R10R10a); NO2; OC(O)R10; N(R10)C(O)R10a; N(R10)S(O)2R10a; N(R10)S(O)R10a; N(R10)C(O)N(R10aR10b); N(R10)C(O)OR10a; OC(O)N(R10R10a); and C1-6alkyl, wherein C1-6alkyl is optionally substituted with one or more R11, which are the same or different; R10, R10a, R10b are independently selected from the group consisting of H; C1-6alkyl, wherein C1-6alkyl is optionally substituted with one or more halogen, which are the same or different; R11 is halogen; CN; C(O)OR12; OR12; C(O)R12; C(O)N(R12R12a); S(O)2N(R12R12a); S(O)N(R12R12a); S(O)2R12; S(O)R12; N(R12)S(O)2N(R12aR12b); N(R12)S(O)N(R12aR12b); SR12; N(R12R12a); NO2; OC(O)R12; N(R12)C(O)R12a; N(R12)S(O)2R12a; N(R12)S(O)R12a; N(R12)C(O)N(R12aR12b); N(R12)C(O)OR12a; or OC(O)N(R12R12a); R12, R12a, R12b are independently selected from the group consisting of H; and C1-6 alkyl, wherein C1-6alkyl is optionally substituted with one or more halogen, which are the same or different; T is phenyl; or 5 to 6 membered aromatic heterocycle, wherein T is substituted with N(R13a)C(O)N(R13bR13) and optionally further substituted with one or more R14, which are the same or different; R14 is halogen; CN; C(O)OR15; OR15; C(O)R15; C(O)N(R15R15a); S(O)2N(R15R15a); S(O)N(R15R15a); S(O)2R15; S(O)R15; N(R15)S(O)2N(R15aR15b); N(R15)S(O)N(R15aR15b); SR15; N(R15R15a); NO2; OC(O)R15; N(R15)C(O)R15a; N(R15)S(O)2R15a; N(R15)S(O)R15a; N(R15)C(O)N(R15R15b); N(R15)C(O)OR15a; OC(O)N(R15R15a); or C1-6 alkyl, wherein C1-6alkyl is optionally substituted with one or more halogen, which are the same or different; R13a, R13b, R15, R15a, R15b are independently selected from the group consisting of H; C1-6alkyl, wherein C1-6alkyl is optionally substituted with one or more halogen, which are the same or different; R13 is H; T2; and C1-6alkyl, wherein C1-6alkyl is optionally substituted with one or more R16, which are the same or different; R16 is halogen; CN; C(O)OR17; OR17; C(O)R17; C(O)N(R17R17a); S(O)2N(R17R17a); S(O)N(R17R17a); S(O)2R17; S(O)R17; N(R17)S(O)2N(R17aR17b); N(R17)S(O)N(R17aR17b); SR7; N(R17R17a); NO2; OC(O)R17; N(R17)C(O)R17a; N(R17)S(O)2R17a; N(R17)S(O)R17a; N(R17)C(O)N(R17aR17b); N(R17)C(O)OR17a; OC(O)N(R17R17a); or T2; R17, R17a, R17b are independently selected from the group consisting of H; and C1-6 alkyl, wherein C1-6 alkyl is optionally substituted with one or more halogen, which are the same or different; Optionally R13, R13b are joined together with the nitrogen atom to which they are attached to form an at least the nitrogen atom as ring heteroatom containing 4 to 7 membered heterocyclyl ring; or 8 to 11 membered heterobicyclyl ring, wherein the 4 to 7 membered heterocyclyl ring; and the 8 to 11 membered heterobicyclyl ring are optionally substituted with one or more R18, which are the same or different; T2 is C3-7cycloalkyl; 4 to 7 membered heterocyclyl; 8 to 11 membered heterobicyclyl; phenyl; naphthyl; indenyl; or indanyl, wherein T2 is optionally substituted with one or more R18, which are the same or different; R18 is halogen; CN; C(O)OR19; OR19; Oxo (═O), where the ring is at least partially saturated; C(O)R19; C(O)N(R19R19a); S(O)2N(R19R19a); S(O)N(R19R19a); S(O)2R19; S(O)R19; N(R19)S(O)2N(R19aR19b); N(R19)S(O)N(R19aR19b); SR19; N(R19R19a); NO2; OC(O)R19; N(R19)C(O)R19a; N(R19)S(O)2R19a; N(R19)S(O)R19a; N(R19)C(O)N(R19aR19b); N(R19)C(O)OR19a; OC(O)N(R19R19a); or C1-6 alkyl, wherein C1-6 alkyl is optionally substituted with one or more R20, which are the same or different; R19, R19a, R19b are independently selected from the group consisting of H; C1-6 alkyl, wherein C1-6 alkyl is optionally substituted with one or more halogen, which are the same or different; R20 is halogen; CN; C(O)OR21; OR21; C(O)R21; C(O)N(R21R21a); S(O)2N(R21R21a); S(O)N(R21R21a); S(O)2R21; S(O)R21; N(R21)S(O)2N(R21aR21b); N(R21)S(O)N(R21aR21b); SR21; N(R21R21a); NO2; OC(O)R21; N(R21)C(O)R21a; N(R21)S(O)2R21a; N(R21)S(O)R21a; N(R21)C(O)N(R21aR21b); N(R21)C(O)OR21a; or OC(O)N(R21R21a); R21, R21a, R21b are independently selected from the group consisting of H; and C1-6 alkyl, wherein C1-6 alkyl is optionally substituted with one or more halogen, which are the same or different. |
