发明名称 |
COMPOSITIONS AND METHODS FOR INCREASING THE SERUM HALF-LIFE OF A THERAPEUTIC AGENT TARGETING COMPLEMENT C5 |
摘要 |
The disclosure features compositions and methods for increasing the half-life of a therapeutic agent (e.g., a C5 antagonist) in the serum of a subject (e.g., a human). Also featured are compositions and methods for: (i) decreasing the frequency by which a therapeutically effective amount of a therapeutic agent must be administered to a human having, suspected of having, or at risk for developing, a medical condition for which the therapeutic agent is effective and (ii) decreasing the dosage of the therapeutic agent required for therapeutic efficacy in a human having, suspected of having, or at risk for developing, a medical condition for which the therapeutic agent is effective. The methods include reducing the serum concentration of the antigen to which the therapeutic agent binds. |
申请公布号 |
WO2014160958(A1) |
申请公布日期 |
2014.10.02 |
申请号 |
WO2014US32209 |
申请日期 |
2014.03.28 |
申请人 |
ALEXION PHARMACEUTICALS, INC. |
发明人 |
HUNTER, JEFFREY, W.;TAMBURINI, PAUL, P. |
分类号 |
A61K39/395;A61K48/00;C07K16/18 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|