BIOSENSOR WITH DUAL GATE STRUCTURE AND METHOD FOR DETECTING CONCENTRATION OF TARGET PROTEIN IN A PROTEIN SOLUTION

摘要

A biosensor with a dual gate structure is disclosed herein. The biosensor comprises: a transistor, a sensing pad, and a plurality of nanostructures. The sensing pad has a conductive area working as another gate and neighboring to the channel layer of the transistor, and a sensing area extended outward from the conductive area to be far away from the channel layer of the transistor, wherein the gate and the conductive area of the sensing pad are separated from each other by the channel layer. The plurality of nanostructures are utilized to bind a first protein to generate a drain current value, when the first protein is combined with the target protein and another drain current value is generated, whereby a variation between the two drain current values is calculated to obtain the concentration of the target protein in the protein solution.

主权项

1. A biosensor with a dual gate structure for detecting a concentration of a target protein in a protein solution, the biosensor comprising:
a transistor having a gate, a source and a drain, wherein a channel layer is formed to establish an electrical connection between the source and the drain; a sensing pad having a conductive area working as another gate and neighboring to the channel layer of the transistor, and a sensing area extended outward from the conductive area to be away from the channel layer of the transistor, wherein the gate and the conductive area of the sensing pad are separated from each other by the channel layer; and wherein the sensing area is utilized to apply a first protein to generate a drain current value via the transistor, when the protein solution is applied on the sensing area to combine the first protein with the target protein and another drain current value is generated via the transistor, the concentration of the target protein in the protein solution is obtained from the difference between the two drain current values.