FUSION PROTEIN COMPRISING ANTI-C-MET ANTIBODY AND VEGF-BINDING FRAGMENT

摘要

There are provided a fusion protein formed by coupling of anti-c-Met antibody and VEGF-binding fragment, a bispecific antibody comprising the fusion protein, a polynucleotide encoding the fusion protein, a transformant comprising the polynucleotide, a pharmaceutical composition comprising the bispecific antibody as an active ingredient, and a method for preparing the bispecific antibody which is targeted at c-Met and VEGF at the same time, with improved anticancer and anti-angiogenesis effects, comprising coupling an anti-c-Met antibody with a VEGF-binding fragment.

主权项

1. A fusion protein comprising (a) an anti-c-Met antibody or an antigen-binding fragment of the anti-c-Met antibody and (b) a VEGF-binding fragment.