| 发明名称 |
T-REG Cell Expansion |
| 摘要 |
This invention relates to methods of expanding T regulatory cells through OX40L and Jagged-1 induced signaling. The methods can be used for treating autoimmune diseases. |
| 申请公布号 |
US2014294792(A1) |
申请公布日期 |
2014.10.02 |
| 申请号 |
US201414186766 |
申请日期 |
2014.02.21 |
| 申请人 |
The Board of Trustees of the University of Illinois |
发明人 |
Prabhakar Bellur |
| 分类号 |
C12N5/0783;A61K35/14 |
主分类号 |
C12N5/0783 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of expanding T-regulatory cells comprising co-culturing said T-regulatory cells with one or more of a OX40L| bone marrow derived dendritic cell culture differentiated in the presence of GM-CSF, a Jagged-1+ bone marrow derived dendritic cell culture differentiated in the presence of GM-CSF and a OX40L+Jagged-1− bone marrow derived dendritic cell culture differentiated in the presence of GM-CSF. |
| 地址 |
Urbana IL US |
