主权项 |
1. A compound of formula (I) or (II): or a pharmaceutically acceptable salt, isomer or prodrug thereof,wherein, Y is CH or N;
R1 is selected from: 1) H; 2) C1-C5 alkyl; 3) C3-C6 cycloalkyl; 4) C1-C5 fluoroalkyl; 5) (CH2)nX, n is an integer of 0-6, X is —OH, —NH2, C1-C6 heteroalkyl, or C3-C7 heterocycloalkyl; 6)wherein each of A1, A2, A3, A4, A5 is independently selected from:
a. H; b. halo; c. —CN; d. —NO2; e. —OH; f. —NH2; g. C1-C6 alkyl; h. C3-C6 cycloalkyl; i. C1-C6 fluoroalkyl; j. C1-C6 heteroalkyl; k. C1-C7 heterocycloalkyl; l. ester, amide, sulfone, sulfoxide, urea formed from the above alkyl;wherein, the heteroatom in the above C1-C6 heteroalkyl or C1-C7 heterocycloalkyl is O, N or S;
R2 is selected from: 1) H; 2) C1-C5 alkyl; 3) C3-C6 cycloalkyl; 4) C1-C5 fluoroalkyl; 5) aryl; 6) heterocycloalkyl;wherein, the heteroatom in the above heterocycloalkyl is O, N or S;
R3 is selected from: 1) H; 2) halo; 3) —NH2, —OH, —CN, —NO2; 4) C1-C5 alkyl; 5) C3-C6 cycloalkyl; 6) aryl; 7)wherein W is selected from —CH2, —CH2CH2, O, S, —NH, —NR; R is C1-C5 alkyl or aryl;
R4 is selected from: 1) H; 2) halo; 3) C1-C5 alkyl; 4) C3-C6 cycloalkyl; 5) aryl;wherein, the above C3-C6 cycloalkyl and aryl each can be independently substituted by 0, 1, 2 or 3 substituents selected from R5;wherein R5 is selected from:
1) H; 2) halo; 3) C1-C3 alkyl; 4) C3-C6 cycloalkyl; 5) C1-C3 alkoxy; 6) C1-C3 fluoroalkyl; 7) heterocycloalkyl; 8) C0-C3 alkylene heterocyclic; 9) phenyl;wherein, the heteroatom in the above heterocycloalkyl or C0-C3 alkylene heterocyclic is O, N or S. |