METHOD FOR PRODUCING (1S,4S,5S)-4-BROMO-6- OXABICYCLO[3.2.1]OCTANE-7-ONE

摘要

The present invention addresses the problem of providing a method for producing (1S,4S,5S)-4-bromo-6-oxabicyclo[3.2.1]octane- 7-one (1), which is important as an intermediate compound for the production of a FXa-inhibiting compound, with high efficiency. A method for producing (1S,4S,5S)- 4-bromo-6-oxabicyclo[3.2.1]octane-7-one (1), said method being characterized by treating a (R)-a-phenylethylamine salt of (S)-3-cyclohexene-1-carboxylic acid with 1,3-dibromo- 5,5-dimethylhydantoin or N-bromosuccinimide in a solvent.