The object of the invention are hammerhead ribozymes directed against the sequence of miR-21 and/or miR-21 precursors, having the ability to specifically cleave miR-21 and/or miR- 21 precursors, and wherein they have acatalytic core with a sequence as shown in SEQ ID No 1. The invention also relates to a composition comprising such ribozymes, a therapeutic agent comprising them, a use of such ribozymes and a method of selective cleavage of miR-21 and/or 1 miR-21 precursors employing such ribozymes.
申请公布号
WO2014155320(A1)
申请公布日期
2014.10.02
申请号
WO2014IB60188
申请日期
2014.03.26
申请人
INSTYTUT CHEMII BIOORGANICZNEJ POLSKIEJ AKADEMII NAUK