发明名称 |
METHODS FOR MODULATING CHEMOTHERAPEUTIC CYTOTOXICITY |
摘要 |
Disclosed herein are methods of reducing cytotoxicity of a chemotherapeutic agent to non-cancer cells by administering to a subject with cancer an effective amount of an agent that inhibits CD47 signaling and a chemotherapeutic agent. Example disclosed methods reduce cardiotoxicity of a chemotherapeutic agent. Also disclosed are methods of increasing cytotoxicity of a chemotherapeutic agent in cancer cells by administering to a subject with a tumor an effective amount of an agent that inhibits CD47 signaling and a chemotherapeutic agent. In some embodiments, the inhibitor of CD47 signaling is administered to the subject before, during, or after the administration of the chemotherapeutic agent. |
申请公布号 |
WO2014160183(A1) |
申请公布日期 |
2014.10.02 |
申请号 |
WO2014US25989 |
申请日期 |
2014.03.13 |
申请人 |
THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
ROBERTS, DAVID, D.;SOTO PANTOJA, DAVID, R. |
分类号 |
A61K39/395;A61K31/137;A61K31/365;A61K31/437;A61K31/505;A61K31/52;A61K31/65;A61K31/704;A61K31/706;A61K31/7064;A61K31/711;A61K31/712;A61P35/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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