O-GlcNAc TAU ANTIBODY AND USE THEREOF

摘要

The invention relates to an antibody that is capable to bind the O-GlcNAcylated tau isoform 2N4R at serine 400. Another object of the invention concerns the use of said antibody for screening molecules for OGA inhibitory activity, and a method for administering a therapeutic molecule to a patient in need of treating Alzheimer's disease. The invention also relates to a method for preparing a monoclonal rabbit antibody.