AUTOMATIC DEVICES FOR REMOTE ISCHEMIC PRECONDITIONING

摘要

Single- or dual-bladder devices for remote ischemic preconditioning and blood pressure monitoring are disclosed along with various oscillometry-based and other methods for detecting systolic and diastolic blood pressure while the ischemic preconditioning treatment is in progress. The devices and methods of the invention provide for delivery of ischemic preconditioning at the lowest effective cuff pressure while closely monitoring patient's hemodynamics. Advantageously, the device of the invention allows both ischemic preconditioning and blood pressure monitoring to be done on the same limb. Disposable battery-powered version of the device of the present invention is especially useful for emergency use with patients suffering from acute myocardial infarction, acute stroke, or acute trauma. Additional device configurations are described for use in a percutaneous intervention and vascular sealing settings.

主权项

1. An automatic device for remote ischemic preconditioning treatment, the device comprising:
a disposable cuff configured to retract about a limb of a subject, a reusable battery-operated rechargeable controller detachably retained on said cuff, said controller is configured to periodically:
inflate said cuff to a cuff pressure at or above a limb occlusion pressure of the subject,maintain said cuff pressure at or above said limb occlusion pressure for a period of at least about one minute, anddeflate said cuff, wherein said cuff and said controller are further configured to be retained about said limb and deliver said remote ischemic preconditioning therapy as one unit, said controller is further configured to initially ether:
inflate said cuff until a set cuff pressure level is reached based on a cuff pressure reading from a sensor, orautomatically determine said cuff pressure based on said cuff pressure reading from the sensor.